Pharmacodynamics flufenicol is a broad spectrum antibiotic in the amidol class, a bacteriosuppressor, and acts by binding with the ribosome 50s subunit to inhibit the synthesis of bacterial proteins. It has strong antibacterial activity against a variety of gram-positive and gram-negative bacteria. Pasteurella hemolyticus, pasteurella multocida and actinobacillus suis pleuropneumoniae were highly sensitive to flufenicol. In vitro, the antimicrobial activity of flufenicol against many microorganisms is similar or stronger than that of sulfenicol, and some bacteria that are resistant to aminools due to acetylation, such as escherichia coli and klebsiella pneumoniae, may still be sensitive to flufenicol.
It is mainly used for the bacterial diseases of pig, chicken and fish caused by sensitive bacteria, such as the respiratory diseases of cattle and pigs caused by pasteurella hemolyticus, pasteurella multocida and actinobacillus pleuropneumoniae. Typhoid and paratyphoid caused by salmonella, chicken cholera, chicken white dysentery, colibacillosis, etc.; fish pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis and other bacteria caused by fish bacterial septicemia, enteritis, erythroderma and soon.
1. Macrolides and lincosamines have the same target as this product, they are combined with the bacterial ribosome 50s subunit, and can produce antagonistic effects when combined.
2. It may antagonize the bactericidal activity of penicillins or aminoglycosides, but it has not been proved in animals.
Amidoalcohol antibiotics, highly sensitive to Pasteurella hemolyticus, Pasteurella multocida and actinobacillus pleuropneumoniae, used for Pasteurella and Escherichia coli infections.
By this product. For internal administration: 0.1 ~ 0.15g per 1kg body weight for pigs and chickens. 2 times a day for 3 to 5 days; 50 to 75mg for fish. Use once a day for 3 to 5 days.
Mixed feeding: This product 100g mix 200 ~ 300kg, continuous use for 3 ~ 5 days.
1. This product has certain immunosuppressive effect when used higher than the recommended dose.
2. It has fetal toxicity, and should be used with caution during pregnancy and lactating livestock.
1. The laying period of laying hens should not be used.
2. Animals with severe immune deficiency or vaccination period should be prohibited.
3. Animals with renal insufficiency should be properly reduced or extended administration interval time.
