Pharmacodynamic lincomycin belongs to lincoamine antibiotics, is a bacteriostatic agent, sensitive bacteria include staphylococcus aureus (including penicillin-resistant strains), streptococcus, pneumococcus, bacillus anthracis, erysipelas suis, some mycoplasma (mycoplasma suis pneumoniae, mycoplasma suis nasal, mycoplasmasuis synovialis), leptospirosis and anaerobic bacteria (such as clostridium difficile, clostridium tetanus, clostridium percapsulatus and most actinomyces). It mainly acts on the 50s subunit of the bacterial ribosome, and exerts an antibacterial effect by inhibiting the extension of the peptide chain and affecting protein synthesis.
The absorption was rapid after intramuscular injection, with a single intramuscular injection of 11mg/kg in pigs and a peak blood concentration of 6.25μg/ml. The plasma protein binding rate was 57%- 72%. It is widely distributed in vivo, with an apparent volume of distribution of 2.8 l/kg in pigs. It is widely distributed in various body fluids and tissues (including bone), among which the concentration of liver and kidney is the highest, and the concentration of tissue drug is several times higher than that of serum in the same period. It can enter the placenta, but it is not easy to penetrate the blood-brain barrier, and it is difficult to reach an effective concentration of the drug in the cerebrospinal fluid when inflammation occurs. It can be distributed to milk, and the concentration in milk is the same as that in plasma. Part of the drug is metabolized in the liver, and the drug form and its metabolites are excreted through bile, urine and milk. Excretion in stool can be delayed for several days, so it has an inhibitory effect on intestinal sensitive microorganisms.
1. When combined with gentamicin, it has a synergistic effect on gram-positive bacteria such as staphylococcus and streptococcus.
2. When combined with aminoglycosides and polypeptide antibiotics, it may enhance the blocking effect on neuromuscular junction. Combined with erythromycin has antagonistic effect, because the site of action is the same,and erythromycin has stronger affinity to the 50s subunit of bacterial ribosomes than this product.
3. It should not be combined with antidiarrheal drugs that inhibit intestinal peristalsis and contain white clay. 4. There is incompatibility with kanamycin, neomycin, etc.
Lincoamine antibiotics. For gram-positive bacteria infection, can also be used for treponemosis and mycoplasma and other infections.
Intramuscular injection: One dose, 0.0165 ~ 0.033ml per 1kg body weight for horses and cattle, 0.033ml for sheep and pigs, once a day; 0.033ml for dogs and cats, twice a day, for 3 to 5 days.
Intramuscular injection may cause transient diarrhea or soft stools. Although rare, necessary measures should be taken to prevent dehydration if they do occur.
